Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure

Summary: Phosphorylation of myofilament proteins critically regulates beat-to-beat cardiac contraction and is typically altered in heart failure (HF). β-Adrenergic activation induces phosphorylation in numerous substrates at the myofilament. Nevertheless, how cardiac β-adrenoceptors (βARs) signal to...

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Principais autores:	Ying Wang, PhD, Meimi Zhao, PhD, Xianhui Liu, PhD, Bing Xu, BS, Gopireddy R. Reddy, PhD, Aleksandra Jovanovic, PhD, Qingtong Wang, MD, PhD, Chaoqun Zhu, Heli Xu, PhD, Elizabeth F. Bayne, PhD, Wenjing Xiang, BS, Douglas G. Tilley, PhD, Ying Ge, PhD, Christopher G. Tate, PhD, Robert Feil, PhD, Joanna C. Chiu, PhD, Donald M. Bers, PhD, Yang K. Xiang, PhD
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2024-08-01
叢編:	JACC: Basic to Translational Science
主題:	β1-adrenoceptor contractility heart failure myofilament myosin light chain nitric oxide synthetase
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2452302X24001049
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