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Phylogenetic Analysis of Pyruvate-Ferredoxin Oxidoreductase, a Redox Enzyme Involved in the Pharmacological Activation of Nitro-Based Prodrugs in Bacteria and Protozoa

The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the distribution of PFOR in selected protozoa and bacteria by applying comparative genomics to test the...

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Principais autores: Seth Duwor, Daniela Brites, Pascal Mäser
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-03-01
coleção:Biology
Assuntos:
pyruvate-ferredoxin oxidoreductase
metronidazole
reductive bioactivation
antimicrobial spectrum
comparative genomics
horizontal gene transfer
Acesso em linha:https://www.mdpi.com/2079-7737/13/3/178
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