Pharmacological Inhibition of the VCP/Proteasome Axis Rescues Photoreceptor Degeneration in RHO^P23H Rat Retinal Explants

Rhodopsin (<i>RHO</i>) misfolding mutations are a common cause of the blinding disease autosomal dominant retinitis pigmentosa (adRP). The most prevalent mutation, <i>RHO^P23H</i>, results in its misfolding and retention in the endoplasmic reticulum (ER). Under homeostatic conditions, misf...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Merve Sen, Oksana Kutsyr, Bowen Cao, Sylvia Bolz, Blanca Arango-Gonzalez, Marius Ueffing
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2021-10-01
Цуврал:	Biomolecules
Нөхцлүүд:	ocular therapy ocular disease retinal organotypic culture retinal degeneration retinitis pigmentosa RHO<sup>P23H</sup>
Онлайн хандалт:	https://www.mdpi.com/2218-273X/11/10/1528
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!