Atazanavir-induced unconjugated hyperbilirubinemia prevents vascular hyporeactivity during experimental human endotoxemia

ObjectiveInflammation-induced free radical release is important in the pathogenesis of several diseases, including atherosclerosis and sepsis. Heme oxygenase (HO) breaks down heme into carbon monoxide, iron, and biliverdin. Biliverdin IXα is directly converted to bilirubin by biliverdin reductase. U...

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Autors principals:	Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M.J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A.D.T.G. Wagener, Peter Pickkers
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-05-01
Col·lecció:	Frontiers in Immunology
Matèries:	antioxidant heme oxygenase system atherosclerosis bilirubin inflammation endothelial dysfunction
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1176775/full
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