Increased Mitochondrial Common Deletion in Oligo-Astheno-Teratozoospermia Samples Is Not Correlated with Increased Global DNA Methylation: Unexpected Results for ATP Levels
Background: mtDNA4977 deletion, linked to impaired mitochondrial function, is reportedly elevated in the spermatozoaof infertile males. We hypothesized that increased deletion load could lead to reduced ATP and S-adenosylmethionine(SAM) levels, thereby disrupting the balance between DNA methylation...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royan Institute (ACECR), Tehran
2025-10-01
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| coleção: | International Journal of Fertility and Sterility |
| Assuntos: | |
| Acesso em linha: | https://www.ijfs.ir/article_722660_c4a859aa11ccb0d520e8392e6f5afa53.pdf |
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