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Integrated network toxicology and multi-omics analysis reveals the role of tobacco-specific carcinogen NNK in idiopathic pulmonary fibrosis pathogenesis

Abstract 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent tobacco-specific nitrosamine that has been widely recognized as a major carcinogen contributing to smoking-related lung diseases. Although its involvement in lung cancer has been extensively studied, the underlying pathogenic...

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Principais autores: Yuwei Lai, Zhenyu Kuang, Wolong Zhou, Aiyuan Zhou, Junjie Jiang, Xiongzhou Zhang, Shujie Liu, Lunxuan Hou, Xin Li, Weifang Cui, Zhangjie Wang, Minghao Duan, Chunfang Zhang, Chaojun Duan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-02-01
Serier:Respiratory Research
Fag:
idiopathic pulmonary fibrosis
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
Network toxicology
Molecular docking
Online adgang:https://doi.org/10.1186/s12931-026-03586-6
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