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Exploring the metabolic burden of surfactin biosynthesis and the metabolic costs of srfA operon expression in Bacillus subtilis

Abstract The biosynthesis of surfactin, a potent lipopeptide biosurfactant produced by Bacillus subtilis, imposes a significant metabolic burden on the host organism. Understanding the metabolic costs associated with surfactin production, specifically the ATP demand and precursor diversion resulting...

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Principais autores: Elvio Henrique Benatto Perino, Eric Hiller, Maliheh Vahidinasab, Sandra Moneta, Bahar Abrishamchi, Kowsala Nagendran, Philipp Hubel, Jens Pfannstiel, Rudolf Hausmann
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-06-01
Serier:Microbial Cell Factories
Fag:
Surfactin
Metabolic burden
Bacillus subtilis
NRPS
Kinetic modelling
Lipopeptides
Online adgang:https://doi.org/10.1186/s12934-026-03047-1
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