LncRNA MALAT1 exhibits positive effects on nucleus pulposus cell biology in vivo and in vitro by sponging miR-503

Abstract Background Intervertebral disc degeneration (IDD) is characterized by the loss of nucleus pulposus cells (NPCs) and phenotypic abnormalities. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are involved in the pathogenesis of IDD. In this study, we aimed to investigate the...

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Detalhes bibliográficos

Principais autores:	Hongyu Zheng, Tingting Wang, Xiangmin Li, Wei He, Zhiqiang Gong, Zhenkai Lou, Bing Wang, Xingguo Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-03-01
coleção:	BMC Molecular and Cell Biology
Assuntos:	Intervertebral disc degeneration Long noncoding RNA MALAT1 microRNA-503 Nucleus pulposus cells Apoptosis MAPK pathway
Acesso em linha:	http://link.springer.com/article/10.1186/s12860-020-00265-2
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