Exploring 2D and 3D QSARs of benzimidazole derivatives as transient receptor potential melastatin 8 (TRPM8) antagonists using MLR and kNN-MFA methodology

TRPM8 is now best known as a cold- and menthol-activated channel implicated in thermosensation. TRPM8 is specifically expressed in a subset of pain- and temperature-sensing neuron. TRPM8 plays a major role in the sensation of cold and cooling substances. TRPM8 is a potential new target for the treat...

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主要な著者:	Kamlendra Singh Bhadoriya, Narender K. Kumawat, Suvarna V. Bhavthankar, Mandar H. Avchar, Dinesh M. Dhumal, Savita D. Patil, Shailesh V. Jain
フォーマット:	Artigo
言語:	Inglês
出版事項:	Springer 2016-09-01
シリーズ:	Journal of Saudi Chemical Society
主題:	Transient receptor potential melastatin 8 (TRPM8) Benzimidazole 2D-QSAR 3D-QSAR MLR kNN-MFA Steric and electrostatic descriptors VLife MDS
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S1319610312001688
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