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Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs

The cytochrome P450 (CYP) enzyme family is the major enzyme system catalyzing the phase I metabolism of xenobiotics, including pharmaceuticals and toxic compounds in the environment. A major part of the CYP-dependent xenobiotic metabolism is due to polymorphic and inducible enzymes, which may, quant...

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Principais autores: Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Elisabetta Scali, Domenica Scumaci, Michele Pellegrino, Stefano Aquaro, Carmela Saturnino, Maria Stefania Sinicropi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-05-01
coleção:Applied Sciences
Assuntos:
metabolites
hydroxylation
monooxygenases
CYP450
hydroxylated metabolites
Acesso em linha:https://www.mdpi.com/2076-3417/13/10/6045
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