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Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Viral RNA-dependent RNA polymerases (RdRps) play a central role not only in viral replication, but also in the genetic evolution of viral RNAs. After binding to an RNA template and selecting 5′-triphosphate ribonucleosides, viral RdRps synthesize an RNA copy according to Watson-Crick base-pairing ru...

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Principais autores: Barbara Selisko, Nicolas Papageorgiou, François Ferron, Bruno Canard
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-01-01
coleção:Viruses
Assuntos:
RNA virus
RNA genome
Flavivirus
RNA polymerase
RNA synthesis
nucleotide inhibitor
selectivity
fidelity
active site
mutation
Acesso em linha:http://www.mdpi.com/1999-4915/10/2/59
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