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p-nitrobenzyloxycarbonyl protective group as key to automated glycan assembly of neutral human milk oligosaccharides

Abstract Human milk oligosaccharides (HMOs) have highly diverse and branched structures that present a significant challenge for chemical synthesis. Here we show that masking the amino group in glucosamine with a p-nitrobenzyloxycarbonyl (pNZ) protecting group enhances coupling and deprotection effi...

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主要な著者: Mei-Huei Lin, Yan-Ting Kuo, Kim Le Mai Hoang, Peter H. Seeberger
フォーマット: Artigo
言語:Inglês
出版事項: Nature Portfolio 2025-12-01
シリーズ:Nature Communications
オンライン・アクセス:https://doi.org/10.1038/s41467-025-66557-3
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