A discovery study of daunorubicin induced cardiotoxicity in a sample of acute myeloid leukemia patients prioritizes P450 oxidoreductase polymorphisms as potential risk factor.

Anthracyclines are very effective chemotherapeutic agents; however, their use is hampered by the treatment-induced cardiotoxicity. Genetic variants that help define patient’s sensitivity to anthracyclines will greatly improve the design of optimal chemotherapeutic regimens. However, identification...

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Principais autores:	Joanna M Lubieniecka, Jinko eGraham, Daniel eHeffner, Randy eMottus, Ronald eReid, Donna eHogge, Tom A Grigliatti, Wayne K Riggs
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2013-11-01
coleção:	Frontiers in Genetics
Assuntos:	Daunorubicin Complex trait Acute Myeloid Leukemia adverse drug reactions POR anthracycline induced cardiotoxicity
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00231/full
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