Differential phenotypes in mice with smooth muscle-specific heterozygous versus homozygous deletion of Stk11

Abstract Liver kinase B1 (Lkb1), encoded by the serine/threonine kinase gene STK11, functions as a critical tumor suppressor associated with Peutz-Jeghers syndrome (PJS). Previous studies have shown that mesenchymal-specific deletion of Stk11 promotes the development of PJS-like polyps in murine mod...

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Hauptverfasser:	Haiping Chen, Guifeng Zhang, Yangjing Jiang, Min Liang, Yijie Huang, Liang Fang, Long Chen, Danrui Xiao, Yunwen Hu, Ben He, Zhaohua Cai
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-12-01
Schriftenreihe:	Scientific Reports
Online-Zugang:	https://doi.org/10.1038/s41598-025-32712-5
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