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TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV

The human silencing hub (HUSH) complex, which includes TASOR, deposits repressive marks on HIV proviruses, resulting in gene repression. Here, Matkovic et al. show that TASOR interacts with RNA Polymerase II, predominantly under its elongating state, and RNA degradation proteins to repress HIV provi...

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Autors principals: Roy Matkovic, Marina Morel, Sophie Lanciano, Pauline Larrous, Benjamin Martin, Fabienne Bejjani, Virginie Vauthier, Maike M. K. Hansen, Stéphane Emiliani, Gael Cristofari, Sarah Gallois-Montbrun, Florence Margottin-Goguet
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2022-01-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-021-27650-5
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