The endocytic receptor protein LRP-1 modulate P-glycoprotein mediated drug resistance in MCF-7 cells.

Multidrug resistance (MDR) is a major obstacle to successful cancer chemotherapy. A typical form of MDR is due to the overexpression of membrane transport proteins., such as Glycoprotein-P (P-gp), resulting in an increased drug efflux preventing drug cytotoxicity. P-gp is mainly localized on the pla...

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Main Authors:	Aubery Henry, Marine Mauperin, Jerome Devy, Stephane Dedieu, Lise Chazee, Cathy Hachet, Christine Terryn, Laurent Duca, Laurent Martiny, Emmanuelle Devarenne-Charpentier, Hassan El Btaouri
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science (PLoS) 2023-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0285834
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