Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [¹¹C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier

[¹¹C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators which may impact the plasma and brain kinetics of...

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Detalhes bibliográficos

Principais autores:	Louise Breuil, Nora Ziani, Sarah Leterrier, Gaëlle Hugon, Fabien Caillé, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sébastien Goutal, Nicolas Tournier
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-11-01
coleção:	Pharmaceutics
Assuntos:	ATP-binding cassette drug–drug interaction membrane transporter neuropharmacology pharmacokinetics
Acesso em linha:	https://www.mdpi.com/1999-4923/14/12/2650
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