Increasing the analytical sensitivity by oligonucleotides modified with para- and ortho-twisted intercalating nucleic acids--TINA.

The sensitivity and specificity of clinical diagnostic assays using DNA hybridization techniques are limited by the dissociation of double-stranded DNA (dsDNA) antiparallel duplex helices. This situation can be improved by addition of DNA stabilizing molecules such as nucleic acid intercalators. Her...

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主要な著者:	Uffe V Schneider, Imrich Géci, Nina Jøhnk, Nikolaj D Mikkelsen, Erik B Pedersen, Gorm Lisby
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2011-01-01
シリーズ:	PLoS ONE
オンライン･アクセス:	http://europepmc.org/articles/PMC3108614?pdf=render
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