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A Biological Signature for the Inhibition of Outer Membrane Lipoprotein Biogenesis

ABSTRACT The outer membrane (OM) of Gram-negative bacteria is an essential organelle that acts as a formidable barrier to antibiotics. Increasingly prevalent resistance to existing drugs has exacerbated the need for antibiotic discovery efforts targeting the OM. Acylated proteins, known as lipoprote...

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Principais autores: Kelly M. Lehman, Hannah C. Smith, Marcin Grabowicz
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2022-06-01
סדרה:mBio
נושאים:
antibiotics
cell envelope
lipoproteins
outer membrane
stress response
גישה מקוונת:https://journals.asm.org/doi/10.1128/mbio.00757-22
תגים: הוספת תג
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