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AMPK/p38 MAPK signaling selectively enhances HIF-induced VEGF-A165 expression under hypoxic and low-glucose conditions in HepG2 cells to promote endothelial cell proliferation and migration

Abstract Background Angiogenesis is essential for tumor development and growth. Vascular endothelial growth factor-A (VEGF-A), a key regulator of angiogenesis, has several isoforms; however, their expression patterns and mechanisms of action are not fully understood. In this study, we aimed to inves...

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Principais autores: Hirohito Hashinokuchi, Munekazu Yamakuchi, Sadayuki Higashi, Kazunori Takenouchi, Akito Tabaru, Yoko Oyama, Chieko Fujisaki, Kiyonori Tanoue, Masashi Okawa, Fuminori Namino, Teruto Hashiguchi
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-05-01
coleção:BMC Cancer
Assuntos:
Tumor angiogenesis
Vascular endothelial growth factor
Hypoxia
Glycolysis
Tumor microenvironment
AMP-activated protein kinase
Acesso em linha:https://doi.org/10.1186/s12885-026-16069-0
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