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Secretome of Mesenchymal Stromal Cells Prevents Myofibroblasts Differentiation by Transferring Fibrosis-Associated microRNAs within Extracellular Vesicles

Fibroblasts differentiation into myofibroblasts is a central event of tissue fibrosis. Multipotent mesenchymal stromal cells (MSCs) secretome can interfere with fibrosis development; despite precise underlying mechanisms remain unclear. In this study, we tested the hypothesis that MSC secretome can...

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Principais autores: Nataliya Basalova, Georgy Sagaradze, Mikhail Arbatskiy, Evgeniy Evtushenko, Konstantin Kulebyakin, Olga Grigorieva, Zhanna Akopyan, Natalia Kalinina, Anastasia Efimenko
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-05-01
Serier:Cells
Fag:
mesenchymal stem/stromal cells
fibrosis
myofibroblasts
secretome
extracellular vesicles
microRNA
Online adgang:https://www.mdpi.com/2073-4409/9/5/1272
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