Targeting of the m6A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancer

Abstract The role of RNA N6-methyladenoine (m6A) eraser AlkB homologue 5 (ALKBH5) in colorectal cancer (CRC) stem cells (CSCs) is unclear. Here, we find that ALKBH5 expression positively correlates with CSC markers in CRC patients. ALKBH5 induces self-renewal and stemness markers in colorectal CSCs...

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Principais autores:	Heming Zhou, Huarong Chen, Weixin Liu, Cong Liang, Shiyan Wang, Kai Yuan, Alvin Ho Kwan Cheung, Yuet Wu, Wei Kang, Henley Cheung, Yanqiang Ding, Qinyao Wei, Hao Su, Tianhui Li, Weimei Luo, Sujun Chen, Chi Chun Wong, Jun Yu
格式:	Artigo
语言:	Inglês
出版:	Nature Portfolio 2025-12-01
丛编:	Nature Communications
在线阅读:	https://doi.org/10.1038/s41467-025-67502-0
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