Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress.

BACKGROUND:Miltefosine (MIL) is an oral antileishmanial drug used for treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Recent reports indicate a significant decline in its efficacy with a high rate of relapse in VL as well as post kala-azar dermal leishmaniasis (PKDL). We investi...

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Bibliografski detalji

Glavni autori:	Deepak Kumar Deep, Ruchi Singh, Vasundhra Bhandari, Aditya Verma, Vanila Sharma, Saima Wajid, Shyam Sundar, V Ramesh, Jean Claude Dujardin, Poonam Salotra
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2017-06-01
Serija:	PLoS Neglected Tropical Diseases
Online pristup:	http://europepmc.org/articles/PMC5470736?pdf=render
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