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SIRT1/PGC-1α Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats

Silent information regulator 1 (SIRT1) exerts neuroprotection in many neurodegenerative diseases. However, it is not clear if SIRT1 has protective effects after intracerebral hemorrhage (ICH)-induced brain injury in rats. Thus, our goal was to examine the influence of SIRT1 on ICH injuries and any u...

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Hlavní autoři: Yang Zhou, Shaohua Wang, Yixin Li, Shanshan Yu, Yong Zhao
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018-01-01
Edice:Frontiers in Molecular Neuroscience
Témata:
SIRT1
PGC-1α
intracerebral hemorrhage
mitochondrial biogenesis
apoptosis
On-line přístup:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00443/full
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