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Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media

Intracellular nucleotide binding and oligomerization domain (NOD) and Toll-like (TLR) receptors have emerged as pivotal sensors of infection. Both Nod1 and Nod2 contain a caspase activation and recruitment domain (CARD) that interacts with the adaptor protein RIP2 (receptor-interaction protein-2). T...

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Principais autores: Arwa Kurabi, Jasmine Lee, Kwang Pak, Anke Leichtle, Allen F Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-07-01
coleção:Frontiers in Genetics
Assuntos:
receptor interacting protein 2 (RIP2)
inflammation
pro-inflammatory cytokines
ear infections
TLR—toll-like receptor
NLR (NOD-like receptors)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2022.893085/full
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