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Genetic modifications of EGLN1 reactivate HbF production in β0-thalassemia/HbE

Reactivation of fetal hemoglobin (HbF, α2γ2) potentially alleviates clinical presentation in β-thalassemia. Prolyl hydroxylase domain enzymes (PHDs) play roles in the canonical oxygen-sensing pathway and maintain the stability of cellular hypoxia-inducible factor α (HIF-α) in response to low oxygen...

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Principais autores: Varit Jan-ngam, Siriraj Boontha, Alisa Tubsuwan, Somsakul Pop Wongpalee, Kanda Fanhchaksai, Adisak Tantiworawit, Pimlak Charoenkwan, Pinyaphat Khamphikham
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2024-09-01
Series:Heliyon
Assuntos:
β-thalassemia
Fetal hemoglobin
Oxygen-sensing pathway
EGLN1
PHD2
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2405844024140510
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