Sex differences in vaccine-induced immunity in mice immunized with integrase-defective lentiviral vector delivering the SARS-CoV-2 Spike protein

IntroductionIntegrase-defective lentiviral vector (IDLV) delivering the optimized SARS-CoV-2 Spike protein induces strong and persistent immunity in mice. Here, we investigate potential sex-dependent differences by comparing female and male mice for germinal center (GC) reactions and Spike-specific...

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Hlavní autoři:	Iole Farina, Alessandra Gallinaro, Martina Borghi, Maria Franca Pirillo, Chiara Falce, Andrea Canitano, Zuleika Michelini, Alice Zappitelli, Antonio Di Virgilio, Mario Picozza, Andrea Cara, Donatella Negri
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-03-01
Edice:	Frontiers in Immunology
Témata:	germinal center integrase-defective lentiviral vector neutralizing antibody preclinical study sex differences Spike
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1778067/full
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