Conserved G-Quadruplex-Forming Sequences in Mammalian <i>TERT</i> Promoters and Their Effect on Mutation Frequency

Somatic mutations in the promoter region of the human telomerase reverse transcriptase (<i>hTERT</i>) gene have been identified in many types of cancer. The <i>hTERT</i> promoter is known to be enriched with sequences that enable the formation of G-quadruplex (G4) structures, whose presence is assoc...

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Detalhes bibliográficos

Principais autores:	Vera V. Panova, Nina G. Dolinnaya, Kirill A. Novoselov, Viktoriia Yu. Savitskaya, Ivan S. Chernykh, Elena A. Kubareva, Andrei V. Alexeevski, Maria I. Zvereva
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-06-01
coleção:	Life
Assuntos:	<i>hTERT</i> promoter G-quadruplex bioinformatics analysis orders of mammals nucleotide substitution block alignment
Acesso em linha:	https://www.mdpi.com/2075-1729/13/7/1478
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