Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence

Abstract Mutations to KRAS are recurrent in lung adenocarcinomas (LUAD) and are daunting to treat due to the difficulties in KRAS oncoprotein inhibition. A possible resolution to this problem may lie with co‐mutations to other genes that also occur in KRAS‐driven LUAD that may provide alternative th...

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Principais autores:	Xiaojing Wang, Shengping Min, Hongli Liu, Nan Wu, Xincheng Liu, Tao Wang, Wei Li, Yuanbing Shen, Hongtao Wang, Zhongqing Qian, Huanbai Xu, Chengling Zhao, Yuqing Chen
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2019-04-01
Serija:	EMBO Molecular Medicine
Teme:	glutaminolysis KRAS lung cancer NF1 PSAT1
Online dostop:	https://doi.org/10.15252/emmm.201809856
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