Complexities in comparing the impact of costimulatory domains on approved CD19 CAR functionality
Abstract Chimeric antigen receptors (CARs) are engineered to target T cells specifically to tumor cells, resulting in the engineered T cell killing the tumor cell. This technology has been developed to target a range of cancers, with the most notable successes in the treatment of B-cell malignancies...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2023-07-01
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| Serier: | Journal of Translational Medicine |
| Fag: | |
| Online adgang: | https://doi.org/10.1186/s12967-023-04372-4 |
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