Immunotherapy rechallenge in gastric cancer: resistance mechanisms, molecular stratification, and precision decision-making

Background/objectivesImmune checkpoint inhibitors (ICIs) have changed the treatment landscape of advanced gastric cancer (GC). However, acquired resistance remains common. For patients who initially benefit and later progress, immunotherapy rechallenge is biologically plausible but still investigati...

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Principais autores:	Yu-cai Jiang, Lin-lin Zheng, Ming-gui Fu, Bi-jin Zheng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Immunology
Assuntos:	gastric cancer immune checkpoint inhibitor immunotherapy molecular stratification precision therapy rechallenge
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1820652/full
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