Novel benzoxazole-based thiosemicarbazide derivatives as new inhibitors of urease and β-Glucuronidase: Synthesis, in vivo anti-nematodal activity and ADMET prediction along with in silico study

Here, we discuss the synthesis of thiosemicarbazide derivatives based on benzoxazole. These compounds were obtained via sequence of reactions. The targeted products were confirmed using a number of spectroscopic methods, including NMR (1H and 13C) and EI-MS. After spectral confirmation all the synth...

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Detalhes bibliográficos
Main Authors: Shoaib Khan, Fazal Rahim, Wajid Rehman, Mohammed M. Alanazi, Ashwag S. Alanazi, Rafaqat Hussain, Muhammad Taha, Farhan Ali, Muhammad Usman Khan, Syed Adnan Ali Shah
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2023-05-01
Colecção:Journal of Saudi Chemical Society
Assuntos:
Benzoxazole synthesis
SAR
Urease
β-Glucuronidase
Nematodal activity
Molecular docking
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1319610323000443
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