CD44 and phosphorylated ERK1/2 coexpression predicts distant metastasis in colorectal cancer based on a study of 1137 Saudi patients

Abstract Cluster of differentiation 44 (CD44) is a transmembrane glycoprotein implicated in tumor progression and metastasis, while phosphorylated ERK1/2 (p-ERK1/2) plays central role in MAPK pathway-driven oncogenic signaling. We investigated the expression and clinical relevance of CD44 in colorec...

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Autors principals:	Sandeep Kumar Parvathareddy, Abdul K. Siraj, Padmanaban Annaiyappanaidu, Fouad Al-Dayel, Khawla S. Al-Kuraya
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	Scientific Reports
Matèries:	Colorectal cancer CD44 ERK1/2 Immunohistochemistry Distant metastasis Biomarkers
Accés en línia:	https://doi.org/10.1038/s41598-025-27690-7
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