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Human induced pluripotent stem cells generated from STING-associated vasculopathy with onset in infancy (SAVI) patients with a heterozygous mutation in the STING gene

We have successfully created induced pluripotent stem cells (iPSC) from patients carrying a heterozygous mutation in the gene encoding STING. The gain-of-function mutation leads to constitutive activation of STING which leads to the development of the disease STING-associated vasculopathy with onset...

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Principais autores: Atul Mehta, Quan Yu, Yangtengyu Liu, Dan Yang, Jizhong Zou, Jeanette Beers, Adriana A de Jesus Rasheed, Andrew T. Rastegar, Raphaela Goldbach-Mansky, Manfred Boehm, Guibin Chen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-12-01
Serier:Stem Cell Research
Online adgang:http://www.sciencedirect.com/science/article/pii/S1873506122003233
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