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Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression

Background: Paeoniflorin (PF) represents the major bioactive constituent of the traditional Chinese medicine plant Paeonia suffruticosa (Ranunculaceae), which has a long history as a folk medicine in Asian. Paeoniflorin, a bitter pinene monoterpene glycoside, has antidepressant effects, but its pote...

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Main Authors: Chaofang Lei, Zhigang Chen, Lili Fan, Zhe Xue, Jianbei Chen, Xihong Wang, Zhen Huang, Yinian Men, Mingzhi Yu, Yueyun Liu, Jiaxu Chen
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
paeoniflorin
CUMS
metabolomics
SLC6A4
TNF
IL6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.904190/full
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