Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS

Nuclear depletion and cytoplasmic accumulation of splicing factor SFPQ are hallmarks of ALS. Here the authors demonstrate a relationship between loss of SFPQ and the emergence in neurites of intron-retaining mRNAs enriched in ALS models and tissues.

Bibliografiske detaljer

Principais autores:	Richard Taylor, Fursham Hamid, Triona Fielding, Patricia M. Gordon, Megan Maloney, Eugene V. Makeyev, Corinne Houart
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2022-11-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-022-34331-4
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