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Genomic Heterogeneity and Clonal Evolution in Gastroesophageal Junction Cancer Revealed by Single Cell DNA Sequencing

Gastroesophageal junction (GEJ) cancer is a tumor that occurs at the junction of stomach and esophagus anatomically. GEJ cancer frequently metastasizes to lymph nodes, however the heterogeneity and clonal evolution process are unclear. This study is the first of this kind to use single cell DNA sequ...

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Gardado en:
Principais autores: Qingke Duan, Chao Tang, Zhao Ma, Chuangui Chen, Xiaobin Shang, Jie Yue, Hongjing Jiang, Yan Gao, Bo Xu
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Assuntos:
single cell sequencing
gastroesophageal junction cancer
genomic heterogeneity
clonal evolution
metastasis
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fonc.2021.672020/full
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