Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1

ABSTRACT Colistin (polymyxin E) and polymyxin B have been used as last-resort agents for treating infections caused by multidrug-resistant Gram-negative bacteria. However, their efficacy has been challenged by the emergence of the mobile colistin resistance gene mcr-1, which encodes a transmembrane...

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Detalhes bibliográficos

Principais autores:	Zhizeng Sun, Timothy Palzkill
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2021-12-01
coleção:	mBio
Assuntos:	antibiotic resistance colistin resistance enzyme kinetics enzyme purification mutagenesis polymyxins
Acesso em linha:	https://journals.asm.org/doi/10.1128/mBio.02776-21
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