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Thymoquinone and aerobic exercise mitigate HFpEF-induced cardiac injury via Apaf1/Cycs axis regulation

IntroductionHeart failure with preserved ejection fraction (HFpEF) is a prevalent clinical syndrome associated with high morbidity and mortality. Oxidative stress, apoptosis, and fibrosis are central to its pathophysiology. This study aimed to investigate the synergistic cardioprotective effects of...

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主要な著者: Zuowei Pei, Shan Gao, Jin Yang, Chang Liu, Yanyan Pan
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2025-10-01
シリーズ:Frontiers in Pharmacology
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オンライン・アクセス:https://www.frontiersin.org/articles/10.3389/fphar.2025.1672570/full
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