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Promotion of beta cell proliferation through DYRK kinase inhibition using the marine natural product breitfussin C

Abstract Pro-inflammatory cytokines, like interleukin-1 beta and interferon gamma, are known to activate signalling pathways causing pancreatic beta cell death and dysfunction, contributing to the onset of diabetes. Targeting cytokine signalling pathways offers a potential strategy to slow or even h...

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Principais autores: Sara Ullsten, Kine Østnes Hansen, Guillaume Axel Petit, Espen Holst Hansen, Jeanette Hammer Andersen
格式: Artigo
語言:Inglês
出版: Nature Portfolio 2025-01-01
叢編:Scientific Reports
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在線閱讀:https://doi.org/10.1038/s41598-025-85178-w
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