Upregulated CCN1 from pleural mesothelial cells alters collagen I conformation and drives fibrosis via ITGB1/MAPK signaling

Abstract Background Pleural mesothelial cells (PMCs) have been identified as key contributors to pleural fibrosis. Cellular communication network factor 1 (CCN1), a matricellular protein, regulates cell–matrix interactions and fibrotic signaling in multiple contexts. However, the specific role and m...

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Prif Awduron:	Xiao-Lin Cui, Lin-Jie Song, Qian Li, Zi-Heng Jia, Xiyong Dai, Meng Wang, Yang-Ping Lv, Shuai-Jun Chen, He-De Zhang, Pei-Pei Cheng, Shu-Yi Ye, Shi-He Hu, Chen-Yue Lian, Li-Mei Liang, Fan Yu, Xin-Liang He, Liang Xiong, Fei Xiang, Xiaorong Wang, Hong Ye, Wan-Li Ma
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2026-04-01
Cyfres:	Cellular & Molecular Biology Letters
Pynciau:	Pleural mesothelial cells CCN1 Type I collagen ITGB1 YAP/TAZ MAPK
Mynediad Ar-lein:	https://doi.org/10.1186/s11658-026-00928-6
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