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Inhibition of Rho‐kinase restores impaired relaxation of airway smooth muscle in rat pups exposed to neonatal hyperoxia

Abstract Neonatal hyperoxia is a key contributor to bronchopulmonary dysplasia (BPD) which is characterized by airway hyperreactivity due to increased contraction and impaired relaxation of airway smooth muscle (ASM). This study investigated whether inhibition of the Rho/Rho‐kinase signaling pathway...

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Principais autores: Ramadan B. Sopi, Qëndrim Thaçi, Thomas M. Raffay, Qëndresa Beqiraj‐Zeqiraj
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-01-01
Serier:Physiological Reports
Fag:
bronchopulmonary dysplasia
fasudil
neonatal hyperoxia
nitric oxide
Rho‐kinase
tracheal smooth muscle
Online adgang:https://doi.org/10.14814/phy2.70728
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