Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method

Messenger RNA (mRNA) vaccines represent a critical avenue for coronavirus disease 2019 (COVID-19) prevention. We developed a COVID-19 mRNA vaccine encoding a codon-optimized full-length ancestral spike (S) protein with a signal peptide, which employs our novel patented co-transcriptional 5′-capping...

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Hlavní autoři:	Kanghyun Choi, Joo-Young Lee, Uk-Il Kim, So-Hyun Park, So-Hee Hong, Yoo-Jin Bang, Yun-Ho Hwang, Jong-Eun Lee, Suhyun Park, Soochong Kim, Sunhee Lee, Ye-Jin Yun, Tae-Gi Uhm, Inyoung Lee, Minju Kwon, EunJi Kwon, Suyeon Song, Yongkyoung Kweon, Heejene Kim, Eun-Young Oh, Jae-Yong Kim, Tae-Young Lee, Seo-Yeon Kim, Se-Eun Kim, You-Jin Kim, Seonock Lee, Ruijing Sun, Eun-Joo Lee, Gamin Kim, Hanah Lim, Byungkyun Kim, Jungho Kim, Dokeun Kim, Jae-Hwan Nam, Sang-Myeong Lee, Kyungjin Kim, Joo-Sung Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-06-01
Edice:	Frontiers in Immunology
Témata:	mRNA vaccine COVID-19 SARS-CoV-2 STP2104 5′-cap analogues capping library screening
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571713/full
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