GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.

Expression of insulin in terminally differentiated non-beta cell types in the pancreas could be important to treating type-1 diabetes. Previous findings led us to hypothesize involvement of kinase inhibition in induction of insulin expression in pancreatic alpha cells.Alpha (αTC1.6) cells and human...

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Hlavní autoři:	Dina Fomina-Yadlin, Stefan Kubicek, Amedeo Vetere, Kai Hui Hu He, Stuart L Schreiber, Bridget K Wagner
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2012-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC3252286?pdf=render
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