Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors

Accumulated preclinical and clinical data show that peripheral restricted opioids provide pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a potent dual μ-/δ-opioid receptor (MOR/DOR) full agonist, and a weak, partial agonist at the κ-opioid receptor (KOR). H...

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Hlavní autoři:	Kristina Puls, Helmut Schmidhammer, Gerhard Wolber, Mariana Spetea
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-01-01
Edice:	Molecules
Témata:	GPCR opioid receptor HS-731 peripheral opioid agonist analgesia binding
On-line přístup:	https://www.mdpi.com/1420-3049/27/3/919
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