Deciphering the emergence of mutations in Pseudomonas aeruginosa after ceftolozane/tazobactam treatment and evaluating therapeutic alternatives

Abstract Objectives Ceftolozane/tazobactam is a relevant option for treating multiresistant Pseudomonas aeruginosa, a major public health problem. Over a 14-month period, we studied the frequency of ceftolozane/tazobactam resistance development and mechanisms underlying resistance in P. aeruginosa i...

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Autors principals:	Léa Bientz, Hugo Boijout, Raoudha Grami, Ulysse Guyet, Marin Lahouati, Melissande Hertzmann, Antony Marques, Audrey Toirot, Sabine Aillerie, Laure Coulange-Mayonnove, Alexis Groppi, Macha Nikolski, Cécile Bébéar, Véronique Dubois
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-12-01
Col·lecció:	BMC Microbiology
Matèries:	Pseudomonas aeruginosa Multidrug resistance Ceftolozane/tazobactam Cephalosporinase New antibiotics
Accés en línia:	https://doi.org/10.1186/s12866-025-04517-z
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