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Expanding the Perspective on PARP1 and Its Inhibitors in Cancer Therapy: From DNA Damage Repair to Immunomodulation

The emergence of PARP inhibitors as a therapeutic strategy for tumors with high genomic instability, particularly those harboring BRCA mutations, has advanced cancer treatment. However, recent advances have illuminated a multifaceted role of PARP1 beyond its canonical function in DNA damage repair....

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Bibliografiske detaljer
Principais autores: Flurina Böhi, Michael O. Hottiger
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-07-01
Serier:Biomedicines
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Online adgang:https://www.mdpi.com/2227-9059/12/7/1617
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