Pulmonary Pharmacokinetics of Antibody and Antibody Fragments Following Systemic and Local Administration in Mice

<b>Objective:</b> This study aimed to investigate the effect of molecular size on the pulmonary pharmacokinetics (PK) of proteins following systemic and local administration in wild-type mice. <b>Methods:</b> A non-cross-reactive antibody trastuzumab, and F(ab′)2, Fab, and scFv fragments of this ant...

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Detalhes bibliográficos

Principais autores:	Prabhas Jagdale, Ashwni Verma, Dhaval K. Shah
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-09-01
coleção:	Pharmaceutics
Assuntos:	pharmacokinetics pulmonary lungs intratracheal instillation bronchoalveolar lavage antibody
Acesso em linha:	https://www.mdpi.com/1999-4923/16/10/1259
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