Microbial Cell Factory of Baccatin III Preparation in Escherichia coli by Increasing DBAT Thermostability and in vivo Acetyl-CoA Supply

Given the rapid development of genome mining in this decade, the substrate channel of paclitaxel might be identified in the near future. A robust microbial cell factory with gene dbat, encoding a key rate-limiting enzyme 10-deacetylbaccatin III-10-O-transferase (DBAT) in paclitaxel biosynthesis to s...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Jia-jun Huang, Tao Wei, Zhi-wei Ye, Qian-wang Zheng, Bing-hua Jiang, Wen-feng Han, An-qi Ye, Pei-yun Han, Li-qiong Guo, Jun-fang Lin
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2022-01-01
Rangatū:	Frontiers in Microbiology
Ngā marau:	baccatin III 10-deacetylbaccatin III-10-O-transferase gene integration semi-rational design thermostability acetyl-CoA supplement
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.803490/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!