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GPR68, A Proton-sensing GPCR, Mediates Acid-induced Visceral NociceptionSummaryWhat You Need to Know

Background & Aims: Localised acidification from immune cell infiltration and heightened glycolysis contributes to colitis pathology by activating acid-sensing receptors such as G protein-coupled receptor 68 (GPR68), a proton-sensing G protein-coupled receptor (GPCR) expressed on immune and strom...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Luke W. Paine, Rohit Gupta, James P. Higham, Javier Aguilera-Lizarraga, Anne Ritoux, Thomas Pritchard, Samuel Nicholson, James R.F. Hockley, Tim Raine, Martin Hausmann, Kyle Bednar, Gerhard Rogler, Fraser Welsh, Ewan St John Smith, David C. Bulmer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2026-01-01
Schriftenreihe:Cellular and Molecular Gastroenterology and Hepatology
Schlagworte:
Colitis
Nociceptors
Pain
Visceral Hypersensitivity
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2352345X25002127
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